Chronic Epstein-Barr virus infection causing both benign and malignant lymphoproliferative disorders

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Chronic Epstein-Barr virus infection causing both benign and malignant lymphoproliferative disorders

The Epstein-Barr virus (EBV) is oncogenic and can transform B cells from a benign to a malignant phenotype. EBV infection is also associated with lymphoid interstitial pneumonia (LIP). Here, we report the case of a 14-year-old boy who was diagnosed with a latent EBV infection and underlying LIP, without any associated immunodeficiency. He had been EBV-seropositive for 8 years. The first clinica...

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Epstein-Barr Virus (EBV), the first human virus related to oncogenesis, was initially identified in a Burkitt lymphoma cell line in 1964. EBV infects over 90% of the world's population. Most infected people maintain an asymptomatic but persistent EBV infection lifelong. However, in some individuals, EBV infection has been involved in the development of cancer and autoimmune disease. Nowadays, o...

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ژورنال

عنوان ژورنال: Korean Journal of Pediatrics

سال: 2014

ISSN: 1738-1061,2092-7258

DOI: 10.3345/kjp.2014.57.9.420